Fit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the 'RxODE' package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
| Version: |
1.1.1-9 |
| Depends: |
R (≥ 3.5) |
| Imports: |
Rcpp (≥ 0.12.3), brew, parallel, methods, ggplot2, memoise, Matrix, n1qn1, fastGHQuad, cli, RcppArmadillo (≥ 0.5.600.2.0), RxODE (≥ 0.9.1-9), nlme, magrittr, tidyr, generics, flextable, stringr, yaml |
| LinkingTo: |
dparser (≥ 0.1.8), RxODE (≥ 0.9.1-3), RcppEigen (≥
0.3.3.3.0), lbfgsb3c, Rcpp, BH, StanHeaders (≥ 2.18.0) |
| Suggests: |
knitr, rmarkdown, dplyr, tibble, data.table, lbfgsb3c, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf, Rvmmin, broom.mixed, dotwhisker, officer, pkgdown, gridExtra, xpose, lotri, rex, minqa, lattice, digest, sys, crayon, lbfgs, dparser, vpc (≥ 1.0.0), huxtable |
| Published: |
2020-06-22 |
| Author: |
Matthew Fidler 
[aut],
Yuan Xiong [aut],
Rik Schoemaker
[aut],
Justin Wilkins
[aut],
Richard Hooijmaijers [aut],
Teun Post [aut],
Wenping Wang [aut, cre],
Robert Leary [ctb],
Mirjam Trame [ctb],
Hadley Wickham [ctb],
Dirk Eddelbuettel [cph],
Johannes Pfeifer [ctb],
Robert B. Schnabel [ctb],
Elizabeth Eskow [ctb],
Emmanuelle Comets [ctb],
Audrey Lavenu [ctb],
Marc Lavielle [ctb],
David Ardia [cph],
Bill Denney [ctb],
Daniel C. Dillon [ctb],
Katharine Mullen [cph],
Ben Goodrich [ctb] |
| Maintainer: |
Wenping Wang <wwang8198 at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: |
https://github.com/nlmixrdevelopment/nlmixr |
| NeedsCompilation: |
yes |
| Citation: |
nlmixr citation info |
| Materials: |
NEWS |
| CRAN checks: |
nlmixr results |