Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020), "Retrospective analysis of a fatal dose-finding trial" <arXiv:2004.12755>.
Version: | 0.1-2 |
Depends: | magrittr, escalation, data.table |
Imports: | methods, dplyr, rlang, stringr, knitr, kableExtra |
Suggests: | rmarkdown, bookdown, tufte, testthat |
Published: | 2020-08-01 |
Author: | David C. Norris [aut, cre, cph] |
Maintainer: | David C. Norris <david at precisionmethods.guru> |
License: | MIT + file LICENSE |
URL: | https://precisionmethods.guru/ |
NeedsCompilation: | no |
Materials: | NEWS |
CRAN checks: | precautionary results |
Reference manual: | precautionary.pdf |
Vignettes: |
Introduction to package 'precautionary' |
Package source: | precautionary_0.1-2.tar.gz |
Windows binaries: | r-devel: precautionary_0.1-2.zip, r-release: precautionary_0.1-2.zip, r-oldrel: precautionary_0.1-2.zip |
macOS binaries: | r-release: precautionary_0.1-2.tgz, r-oldrel: precautionary_0.1-2.tgz |
Old sources: | precautionary archive |
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