Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
| Version: | 1.0.2 |
| Depends: | R (≥ 3.0.0), coda (≥ 0.13), ggplot2, stats |
| Imports: | rjags, arrayhelpers, MASS, reshape2, plyr, dplyr, RColorBrewer, gridExtra, kableExtra, knitr |
| Published: | 2020-03-09 |
| Author: | Lu Zhang, Jun Yin |
| Maintainer: | Lu Zhang <luzhangstat at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| SystemRequirements: | JAGS (http://mcmc-jags.sourceforge.net) |
| Materials: | README NEWS |
| CRAN checks: | phase1PRMD results |
| Reference manual: | phase1PRMD.pdf |
| Package source: | phase1PRMD_1.0.2.tar.gz |
| Windows binaries: | r-devel: phase1PRMD_1.0.2.zip, r-release: phase1PRMD_1.0.2.zip, r-oldrel: phase1PRMD_1.0.2.zip |
| macOS binaries: | r-release: phase1PRMD_1.0.2.tgz, r-oldrel: phase1PRMD_1.0.2.tgz |
| Old sources: | phase1PRMD archive |
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