Perform assessment of synergy/antagonism for drug combinations based on the Loewe additivity model, following Harbron's approach (Statistics in Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling of the drug interaction index and supports "2-stage" estimation in addition to "1-stage" estimation, including bootstrap-based confidence intervals. The method requires data on the monotherapy responses and the package accommodates both checkerboard and ray designs. Functions are available for graphical exploration of model goodness-of-fit and diagnostics, as well as for synergy/antagonism assessment in 2D and 3D.
| Version: | 1.1.1 |
| Depends: | R (≥ 2.10) |
| Imports: | ggplot2, minpack.lm, BIGL (≥ 0.9), rgl, nlme, Deriv, methods, stats |
| Suggests: | knitr, rmarkdown, testthat, Cairo |
| Published: | 2019-10-15 |
| Author: | Maxim Nazarov, Nele Goeyvaerts, Chris Harbron (original article and code) |
| Maintainer: | Maxim Nazarov <maxim.nazarov at openanalytics.eu> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | drugCombo results |
| Reference manual: | drugCombo.pdf |
| Vignettes: |
Drug interaction modeling based on Loewe additivity following Harbron's approach |
| Package source: | drugCombo_1.1.1.tar.gz |
| Windows binaries: | r-devel: drugCombo_1.1.1.zip, r-release: drugCombo_1.1.1.zip, r-oldrel: drugCombo_1.1.1.zip |
| macOS binaries: | r-release: drugCombo_1.1.1.tgz, r-oldrel: drugCombo_1.1.1.tgz |
| Old sources: | drugCombo archive |
Please use the canonical form https://CRAN.R-project.org/package=drugCombo to link to this page.