Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.
| Version: | 0.1.0 |
| Depends: | R (≥ 2.10) |
| Imports: | igraph, dplyr, ROCR, visNetwork |
| Suggests: | knitr, rmarkdown |
| Published: | 2019-02-24 |
| Author: | Junwei Han [ctb, cre], Jieyi Di [aut], Baotong Zheng [aut] |
| Maintainer: | Junwei Han <hanjunwei1981 at 163.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | PriorCD results |
| Reference manual: | PriorCD.pdf |
| Vignettes: |
Vignette Title |
| Package source: | PriorCD_0.1.0.tar.gz |
| Windows binaries: | r-devel: PriorCD_0.1.0.zip, r-release: PriorCD_0.1.0.zip, r-oldrel: PriorCD_0.1.0.zip |
| macOS binaries: | r-release: PriorCD_0.1.0.tgz, r-oldrel: PriorCD_0.1.0.tgz |
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