The InnoDB table compression is automatic and applies to all columns and index values. The columns can still be tested with operators such as LIKE, and sort operations can still use indexes even when the index values are compressed. Because indexes are often a significant fraction of the total size of a database, compression could result in significant savings in storage, I/O or processor time. The compression and decompression operations happen on the database server, which likely is a powerful system that is sized to handle the expected load.

If you compress data such as text in your application, before it is inserted into the database, You might save overhead for data that does not compress well by compressing some columns and not others. This approach uses CPU cycles for compression and uncompression on the client machine rather than the database server, which might be appropriate for a distributed application with many clients, or where the client machine has spare CPU cycles.

Of course, it is possible to combine these approaches. For some applications, it may be appropriate to use some compressed tables and some uncompressed tables. It may be best to externally compress some data (and store it in uncompressed InnoDB tables) and allow InnoDB to compress (some of) the other tables in the application. As always, up-front design and real-life testing are valuable in reaching the right decision.