SEA performs simultaneous feature-set testing for (gen)omics data. It tests the unified null hypothesis controls the family-wise error rate for all possible pathways. The unified null hypothesis is defined as: "The proportion of true features in the set is less than or equal to the threshold c", where c is selected by the user. Family-wise error rate control is provided through use of closed testing with Simes test. For more information on closed testing with Simes see Goeman et al. (2019) <doi:10.1093/biomet/asz041> and for more information about the properties and performance of SEA procedure see Ebrahimpoor et al. (2019) <doi:10.1093/bib/bbz074>.
| Version: | 2.1.1 |
| Depends: | R (≥ 2.10), hommel (≥ 1.4), ggplot2 |
| Suggests: | knitr, rmarkdown |
| Published: | 2020-03-23 |
| Author: | Mitra Ebrahimpoor |
| Maintainer: | Mitra Ebrahimpoor <mitra.ebrahimpoor at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: | https://github.com/mitra-ep/rSEA |
| NeedsCompilation: | no |
| Materials: | README |
| CRAN checks: | rSEA results |
| Reference manual: | rSEA.pdf |
| Vignettes: |
rSEA R package |
| Package source: | rSEA_2.1.1.tar.gz |
| Windows binaries: | r-devel: rSEA_2.1.1.zip, r-release: rSEA_2.1.1.zip, r-oldrel: rSEA_2.1.1.zip |
| macOS binaries: | r-release: rSEA_2.1.1.tgz, r-oldrel: rSEA_2.1.1.tgz |
| Old sources: | rSEA archive |
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