Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.
| Version: | 0.12 |
| Depends: | dfcrm, nnet |
| Imports: | stats |
| Published: | 2019-03-15 |
| Author: | Nolan A. Wages |
| Maintainer: | "Varhegyi, Nikole E. (nev4g)" <nev4g at virginia.edu> |
| License: | GPL-2 |
| NeedsCompilation: | no |
| CRAN checks: | pocrm results |
| Reference manual: | pocrm.pdf |
| Package source: | pocrm_0.12.tar.gz |
| Windows binaries: | r-devel: pocrm_0.12.zip, r-release: pocrm_0.12.zip, r-oldrel: pocrm_0.12.zip |
| macOS binaries: | r-release: pocrm_0.12.tgz, r-oldrel: pocrm_0.12.tgz |
| Old sources: | pocrm archive |
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