pksensi 1.2.0

• update the route to load example model
• update the default MCSim version to 6.2.0
• Switch the contact mail to d99622005@ntu.edu.tw

pksensi 1.1.7

• Suggested to use Rtools40
• Added parallel method in solve_mcsim()
• Fixed bug in heat_check()
• Added message of display info in heat_check() function
• Improved heat_check() to display the indices based on the setting cut-off

pksensi 1.1.6

• Improved heat_check() to only show influential parameters as default
• Updated check() to return the SI and CI in a list

pksensi 1.1.5

• solve_mcsim(): extense the flexible for the model in subfolder
• Update the vignettes (add deSolve modeling example)

pksensi 1.1.4

• Replace SE to NSE in heat_check()
• Update manual

pksensi 1.1.3

• Update solve_fun() to run deSolve with Pure R code
• set default mxstep = 5000 in mcsim_install()

pksensi 1.1.2

• Add timer in solve_fun()
• Add default MCSim version = '6.1.0' in compile_model()
• Update pksim(): Can customize xlab and ylab
• Update pbtk1cpt model: Add body weight
• Update vignettes
• Fix bug: Create .dll in win10 through compile_model()
• Fix bug: plot() cannot display variable name when using character
• Revise the mcsim_version() for Windows OS

pksensi 1.1.1

Fix Bug:

• Add rtol and atol in solve_mcsim()
• Switch default compiler from Clang to GCC in MacOS
• Fix the mName problem under Windows environment in solve_mcsim()

Update vignette

• Remind to set the mxstep to 5000 in APAP-PBPK example
• Add note to APAP vignette (Set atol and rtol)

Update function

• mcsim_version() can work in MCSim_under_R
• Stop the function when compile error in compile_model()
• Revise the default name of output to “simmc.out” and “setpts.out” in solve_mcsim()

pksensi 1.1.0

Fix Bug:

• Used single time point in solve_mcsim()

Update function:

Installation

• Update the default MCSim version to version = 6.1.0 in install_mcsim()
• Adopt the name of model file (“model.R.exe”) to MCSim_under_R project

Modeling

• Change assignment n to monte_carlo in solve_mcsim()
• Revise the default name of output to “sim.out” and “setpoint.out” in solve_mcsim()
• Add solving message to track time spend in solve_mcsim()
• Add assignment tell = T to automatically combine the output y in decoupling simulation x in solve_fun() and solve_mcsim()

Plot

• Transfer the log-transformed value to natural scale in pksim()
• Revise the discrete time condition to length(times) < 16 in heat_check()

pksensi 1.0.1

New vignette:

• Add “PBTK 1-compartment model”
• Add “Acetaminophen-PBPK model”

New example:

• Update example in solve_mcsim()

New function:

• Add pbtk1cpt_model()
• Add pbpk_apap_model()
• Add function mcsim_version()

NEW dataset:

• Add APAP dataset

Fix Bug:

• Fix the order argument in heat_check()
• Add message in generate_infile()

Update function:

• Remove argument params in solve_fun()
• No need to define infile.name and outfile.name in solve_mcsim()

Change:

• Change function’s name install_mcsim() to mcsim_install()

pksensi 1.0.0

• Initial release in CRAN