R implementation of a multivariate meta-analysis of randomized controlled trials (RCT) with the difference in restricted mean survival times (RMSTD). Use this package with individual patient level data from an RCT for a time-to-event outcome to determine combined effect estimates according to 4 methods: 1) a univariate meta-analysis using observed treatment effects, 2) a univariate meta-analysis using effects predicted by fitted Royston-Parmar flexible parametric models, 3) multivariate meta-analysis with analytically derived covariance, 4) multivariate meta-analysis with bootstrap derived covariance. This package computes all combined effects and provides an RMSTD curve with combined effect estimates and their confidence intervals.
| Version: | 1.0.0 |
| Depends: | R (≥ 3.4.0), rstpm2 |
| Imports: | mvmeta, meta, survival, survRM2, graphics |
| Published: | 2018-12-18 |
| Author: | Isabelle Weir [aut, cre], Lu Tian [aut], Ludovic Trinquart [aut] |
| Maintainer: | Isabelle Weir <iweir at bu.edu> |
| License: | GPL-2 |
| URL: | https://github.com/iweir/metaRMST |
| NeedsCompilation: | no |
| Materials: | README |
| In views: | MetaAnalysis |
| CRAN checks: | metaRMST results |
| Reference manual: | metaRMST.pdf |
| Package source: | metaRMST_1.0.0.tar.gz |
| Windows binaries: | r-devel: metaRMST_1.0.0.zip, r-release: metaRMST_1.0.0.zip, r-oldrel: metaRMST_1.0.0.zip |
| macOS binaries: | r-release: metaRMST_1.0.0.tgz, r-oldrel: metaRMST_1.0.0.tgz |
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