Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.
| Version: | 0.1.1 |
| Imports: | diagram, dfcrm |
| Suggests: | knitr, rmarkdown, testthat |
| Published: | 2019-08-20 |
| Author: | Christina Yap [aut, cre], Daniel Slade [aut], Kristian Brock [aut], Yi Pan [aut] |
| Maintainer: | Christina Yap <yapchristina17 at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | dtpcrm results |
| Reference manual: | dtpcrm.pdf |
| Vignettes: |
dtpcrm: Dose Transition Pathways with Continual Reassessment Method |
| Package source: | dtpcrm_0.1.1.tar.gz |
| Windows binaries: | r-devel: dtpcrm_0.1.1.zip, r-release: dtpcrm_0.1.1.zip, r-oldrel: dtpcrm_0.1.1.zip |
| macOS binaries: | r-release: dtpcrm_0.1.1.tgz, r-oldrel: dtpcrm_0.1.1.tgz |
| Old sources: | dtpcrm archive |
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