Simulate genotypes for case-parent triads, case-control, and quantitative trait samples with realistic linkage diequilibrium structure and allele frequency distribution. For studies of epistasis one can simulate models that involve specific SNPs at specific sets of loci, which we will refer to as "pathways". TriadSim generates genotype data by resampling triad genotypes from existing data. The details of the method is described in the manuscript under preparation "Simulating Autosomal Genotypes with Realistic Linkage Disequilibrium and a Spiked in Genetic Effect" Shi, M., Umbach, D.M., Wise A.S., Weinberg, C.R.
| Version: | 0.2.0 |
| Depends: | R (≥ 3.2.2) |
| Imports: | methods, parallel, snpStats, foreach, doParallel |
| Suggests: | knitr, rmarkdown |
| Published: | 2020-07-12 |
| Author: | Min Shi [aut, cre] |
| Maintainer: | Min Shi <shi2 at niehs.nih.gov> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | README NEWS |
| CRAN checks: | TriadSim results |
| Reference manual: | TriadSim.pdf |
| Vignettes: |
TriadSim Vignette |
| Package source: | TriadSim_0.2.0.tar.gz |
| Windows binaries: | r-devel: TriadSim_0.2.0.zip, r-release: TriadSim_0.2.0.zip, r-oldrel: TriadSim_0.2.0.zip |
| macOS binaries: | r-release: TriadSim_0.2.0.tgz, r-oldrel: TriadSim_0.2.0.tgz |
| Old sources: | TriadSim archive |
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