RefFreeEWAS: EWAS using Reference-Free DNA Methylation Mixture Deconvolution
Reference-free method for conducting EWAS while deconvoluting DNA methylation
arising as mixtures of cell types. The older method
(Houseman et al., 2014,<doi:10.1093/bioinformatics/btu029>) is similar to
surrogate variable analysis (SVA and ISVA), except that it makes additional use
of a biological mixture assumption.
The newer method (Houseman et al., 2016, <doi:10.1186/s12859-016-1140-4>) is similar
to non-negative matrix factorization, with additional constraints
and additional utilities.
| Version: |
2.2 |
| Depends: |
R (≥ 3.2.2), quadprog |
| Published: |
2018-12-14 |
| Author: |
E. Andres Houseman, Sc.D. |
| Maintainer: |
E. Andres Houseman <eahouseman at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| CRAN checks: |
RefFreeEWAS results |
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Reverse dependencies:
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