Package: PriorCD
Type: Package
Title: Prioritizing Cancer Drugs for Interested Cancer
Version: 0.1.0
Authors@R: c(
  person(given = "Junwei", family = "Han",email = "hanjunwei1981@163.com",role = c("ctb", "cre")), 
  person(given = "Jieyi", family = "Di",email = "dijy_0419@yeah.net",role = "aut"), 
  person(given = "Baotong", family = "Zheng",email = "btzheng1116@163.com",role = "aut"))
Maintainer: Junwei Han <hanjunwei1981@163.com>
Description: Prioritize candidate cancer drugs for drug repositioning based on the random walk with restart algorithm in a drug-drug functional similarity network. 1) We firstly constructed a drug-drug functional similarity network by integrating pathway activity and drug activity derived from the NCI-60 cancer cell lines. 2) Secondly, we calculated drug repurposing score according to a set of approved therapeutic drugs of interested cancer based on the random walk with restart algorithm in the drug-drug functional similarity network. 3) Finally, the permutation test was used to calculate the statistical significance level for the drug repurposing score.
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
RoxygenNote: 6.1.1
Imports: igraph, dplyr, ROCR, visNetwork
Suggests: knitr, rmarkdown
Depends: R (>= 2.10)
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2019-02-10 08:47:49 UTC; zbt
Author: Junwei Han [ctb, cre],
  Jieyi Di [aut],
  Baotong Zheng [aut]
Repository: CRAN
Date/Publication: 2019-02-24 16:40:06 UTC
Built: R 3.6.3; ; 2020-08-05 06:02:44 UTC; windows
