# Modeling Using PLETHEM

#### Salil N. Pendse

#### 2020-07-16

# Installing PLETHEM

PLETHEM can be run installed from CRAN

    install.packages(plethem)

The most recent development version can be installed from

    devtools::install_github("Scitovation/plethem")

and then use

    library(plethem)

to start using PLETHEM ## Running rapidPBPK models The rapidPBPK model within PLETHEM can be used to run forward dosimetry, monte carlo analysis, reverse dosimetry, and route to route extrapolation workflows. To start the rapidPBPK application

    interactivePBPK()

## Running HT-IVIVE models in PLETHEM

The High-Throughput IVIVE workflow within PELTHEM can be used to extrapolate in vitro points of depature to equivalent applied dose in vivo TO start the HT-IVIVE application

    interactiveHT()

## Running HTTK models

Models within the HTTK package can also be run using the same interactive modeling interface you saw previously. These models require the chemicals be a part of HTTK’s internal chemical database. Chemicals can be added to httk’s chemical database using the httk function

    httk::add_chemtable(table)

This can be simplified if you are using RStudio. The gadget developed for adding data to httk’s chemical database can be invoked by running the command

    addChemsToHTTK()

Once the chemical is added to the HTTK database, a new httk PBPK project can be created by using the commands above but replacing value of the parameter model to “httk_pbtk”