Package: nlmixr
Type: Package
Title: Nonlinear Mixed Effects Models in Population Pharmacokinetics
        and Pharmacodynamics
Depends: R (>= 3.5)
Imports: Rcpp (>= 0.12.3), brew, parallel, methods, ggplot2, memoise,
        Matrix, n1qn1, fastGHQuad, cli, RcppArmadillo (>= 0.5.600.2.0),
        RxODE(>= 0.9.1-9), nlme, magrittr, tidyr, generics, flextable,
        stringr, yaml
Suggests: knitr, rmarkdown, dplyr, tibble, data.table, lbfgsb3c,
        testthat, madness, devtools, expm, matrixcalc, reshape2,
        nloptr, ucminf, Rvmmin, broom.mixed, dotwhisker, officer,
        pkgdown, gridExtra, xpose, lotri, rex, minqa, lattice, digest,
        sys, crayon, lbfgs, dparser, vpc (>= 1.0.0), huxtable
Version: 1.1.1-9
Authors@R: c(person("Matthew","Fidler",
      role = "aut", email = "matthew.fidler@gmail.com",
      comment=c(ORCID="0000-0001-8538-6691")),
   person("Yuan", "Xiong", 
      role = "aut", email = "yuan.xiong@gmail.com"),
   person("Rik", "Schoemaker", 
      role = "aut", email = "rik.schoemaker@occams.com",
      comment=c(ORCID="0000-0002-7538-3005")),
   person("Justin", "Wilkins", 
      role = "aut", email = "justin.wilkins@occams.com",
      comment=c(ORCID="0000-0002-7099-9396")),
   person("Richard", "Hooijmaijers", email = "richardhooijmaijers@gmail.com",
      role = "aut"),
   person("Teun","Post",
      role = "aut", email = "t.post@lapp.nl"),   
   person("Wenping", "Wang", 
      role = c("aut", "cre"), email = "wwang8198@gmail.com"),
   person("Robert","Leary", role = "ctb"),
   person("Mirjam","Trame", role = "ctb"),
   person("Hadley","Wickham", role = "ctb"),
   person("Dirk","Eddelbuettel",
      role = "cph", email = "edd@debian.org"),
   person("Johannes", "Pfeifer",role="ctb"),
   person("Robert B.", "Schnabel",role="ctb"),
   person("Elizabeth", "Eskow", role="ctb"),
   person("Emmanuelle", "Comets", role="ctb", email="emmanuelle.comets@inserm.fr"),
   person("Audrey", "Lavenu", role="ctb"),
   person("Marc", "Lavielle", role="ctb"),
   person("David","Ardia",role = "cph"),
   person("Bill", "Denney", role=c("ctb"),
      email="wdenney@humanpredictions.com",
      comment=c(ORCID="0000-0002-5759-428X")),
   person("Daniel C.", "Dillon", role="ctb"),
   person("Katharine","Mullen",role = "cph"),
   person("Ben", "Goodrich", role = "ctb")
   )
Description: Fit and compare nonlinear mixed-effects models in differential
    equations with flexible dosing information commonly seen in pharmacokinetics
    and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 
    <doi:10.1007/s10928-015-9409-1>). Differential equation solving is 
    by compiled C code provided in the 'RxODE' package
    (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
License: GPL (>= 2)
NeedsCompilation: yes
LinkingTo: dparser(>= 0.1.8), RxODE(>= 0.9.1-3), RcppEigen (>=
        0.3.3.3.0), lbfgsb3c, Rcpp, BH, StanHeaders(>= 2.18.0)
URL: https://github.com/nlmixrdevelopment/nlmixr
LazyData: true
RoxygenNote: 7.1.0.9000
Biarch: true
Packaged: 2020-06-22 02:26:10 UTC; annie
Maintainer: Wenping Wang <wwang8198@gmail.com>
Author: Matthew Fidler [aut] (<https://orcid.org/0000-0001-8538-6691>),
  Yuan Xiong [aut],
  Rik Schoemaker [aut] (<https://orcid.org/0000-0002-7538-3005>),
  Justin Wilkins [aut] (<https://orcid.org/0000-0002-7099-9396>),
  Richard Hooijmaijers [aut],
  Teun Post [aut],
  Wenping Wang [aut, cre],
  Robert Leary [ctb],
  Mirjam Trame [ctb],
  Hadley Wickham [ctb],
  Dirk Eddelbuettel [cph],
  Johannes Pfeifer [ctb],
  Robert B. Schnabel [ctb],
  Elizabeth Eskow [ctb],
  Emmanuelle Comets [ctb],
  Audrey Lavenu [ctb],
  Marc Lavielle [ctb],
  David Ardia [cph],
  Bill Denney [ctb] (<https://orcid.org/0000-0002-5759-428X>),
  Daniel C. Dillon [ctb],
  Katharine Mullen [cph],
  Ben Goodrich [ctb]
Repository: CRAN
Date/Publication: 2020-06-22 08:50:08 UTC
Built: R 4.1.0; x86_64-w64-mingw32; 2020-08-03 13:56:40 UTC; windows
Archs: i386, x64
