Package: cit
Type: Package
Title: Causal Inference Test
Version: 2.2
Date: 2017-12-11
Author: Joshua Millstein
Maintainer: Joshua Millstein <joshua.millstein@usc.edu>
Description: A likelihood-based hypothesis testing approach is implemented for assessing causal mediation. For example, it could be used to test for mediation of a known causal association between a DNA variant, the 'instrumental variable', and a clinical outcome or phenotype by gene expression or DNA methylation, the potential mediator. Another example would be testing mediation of the effect of a drug on a clinical outcome by the molecular target. The hypothesis test generates a p-value or permutation-based FDR value with confidence intervals to quantify uncertainty in the causal inference. The outcome can be represented by either a continuous or binary variable, the potential mediator is continuous, and the instrumental variable can be continuous or binary and is not limited to a single variable but may be a design matrix representing multiple variables.
SystemRequirements: gsl (with development libraries)
License: Artistic-2.0
LazyLoad: yes
NeedsCompilation: yes
Packaged: 2017-12-15 20:30:07 UTC; joshuamillstein
Repository: CRAN
Date/Publication: 2017-12-15 20:46:00 UTC
Built: R 4.1.0; x86_64-w64-mingw32; 2020-07-30 06:21:55 UTC; windows
Archs: i386, x64
