# Dose Titration Algorithm Tuning

## Documentation for package ‘DTAT’ version 0.3-4

- DESCRIPTION file.
- User guides, package vignettes and other documentation.

## Help Pages

DTAT-package | Dose Titration Algorithm Tuning: a Framework for Dose Individualization in Drug Development
as_d3_data-method | Convert a DE object to JSON
DE-class | An S4 class for simulating dose-titration study designs
de.bioRxiv.240846 | Simulated '3+3/PC' dose-titration study from bioRxiv paper no. 240846
dose.survfit | Calculate a dose-survival curve from a dose titration study, adding a confidence band
dose.survival | Extract interval-censored dose tolerance data from a dose titration study
ds.curve | Extract the dose-survival curve, with its upper and lower confidence band limits
DTAT | Dose Titration Algorithm Tuning: a Framework for Dose Individualization in Drug Development
dtat1000 | Precomputed neutrophil-guided chemotherapy dose titration for 1000 simulated subjects.
newton.raphson | A dose titration algorithm (DTA) 'factory' based on the Newton-Raphson heuristic
Onoue.Friberg | POMP PK/PD model for docetaxel, combining Onoue et al (2016) with Friberg et al (2002)
plot-method | Plot a DE object as an interactive htmlwidget
runDTATapp | Run Shiny apps included in package DTAT
scaled | Power-law scaling for doses
seq.function | A seq method supporting custom-scaled plot axes.
sim | Environment for simulation global variables.
titrate | Perform neutrophil-guided dose titration of a chemotherapy drug.
titration | Simulate a '3+3/PC' dose-titration trial
titration-method | Simulate a '3+3/PC' dose-titration trial