Package: httk
Version: 2.0.1
Date: 2020-02-27
Title: High-Throughput Toxicokinetics
Description: Functions and data tables for simulation and statistical analysis 
             of chemical toxicokinetics ("TK") as in Pearce et al. (2017) 
             <doi:10.18637/jss.v079.i04>. Chemical-specific in vitro 
             data have been obtained from relatively high throughput 
             experiments. Both physiologically-based ("PBTK") and empirical 
             (e.g., one compartment) "TK" models can be parameterized for 
             several hundred chemicals and multiple species. These models are 
             solved efficiently, often using compiled (C-based) code. A Monte 
             Carlo sampler is included for simulating biological variability 
             (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>) 
             and measurement limitations. Calibrated methods are included for 
             predicting tissue:plasma partition coefficients and volume of 
             distribution 
             (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>). 
             These functions and data provide a set of tools for 
             in vitro-in vivo extrapolation ("IVIVE") of high throughput 
             screening data (e.g., Tox21, ToxCast) to real-world exposures via 
             reverse dosimetry (also known as "RTK") 
             (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).
Authors@R: c(
           person("John", "Wambaugh", email = "wambaugh.john@epa.gov", 
             role = c("aut", "cre"),
             comment = c(ORCID = "0000-0002-4024-534X")), 
           person("Robert", "Pearce", role = c("aut"),
             comment = c(ORCID = "0000-0003-3168-4049")), 
           person("Caroline", "Ring", email = "cring@toxstrategies.com", 
             role = c("aut"), comment = c(ORCID = "0000-0002-0463-1251")), 
           person("Greg", "Honda", email = "honda.gregory@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0001-7713-9850")), 
           person("Mark", "Sfeir", email = "sfeir.mark@epa.gov", 
             role = c("aut")), 
           person("Matt", "Linakis", email = "matthew.linakis.1@us.af.mil", 
             role = c("aut"), comment = c(ORCID = "0000-0003-0526-2395")), 
           person("Jimena", "Davis", role = c("ctb")), 
           person("James", "Sluka", email = "jsluka@indiana.edu", 
             role = c("ctb"), comment = c(ORCID = "0000-0002-5901-1404")), 
           person("Nisha", "Sipes", email = "nisha.sipes@nih.gov", 
             role = c("ctb"), comment = c(ORCID = "0000-0003-4203-6426")), 
           person("Barbara", "Wetmore", email = "wetmore.barbara@epa.gov", 
             role = c("ctb")), 
           person("Woodrow", "Setzer", role = c("ctb"),
             comment = c(ORCID = "0000-0002-6709-9186"))
           )
Depends: R (>= 2.10)
Imports: deSolve, msm, data.table, survey, mvtnorm, truncnorm, stats,
        graphics, utils, magrittr, purrr, methods
Suggests: ggplot2, knitr, rmarkdown, R.rsp, GGally, gplots, scales,
        EnvStats, MASS, RColorBrewer, TeachingDemos, classInt, ks,
        stringr, reshape, reshape2, gdata, viridis, CensRegMod,
        gmodels, colorspace, cowplot, ggrepel, dplyr, forcats, smatr,
        gtools, gridExtra
License: GPL-3
LazyData: true
Encoding: UTF-8
VignetteBuilder: knitr, R.rsp
RoxygenNote: 7.0.2
URL:
        https://www.epa.gov/chemical-research/rapid-chemical-exposure-and-dose-research
BugReports: https://github.com/USEPA/CompTox-ExpoCast-httk
NeedsCompilation: yes
Packaged: 2020-03-01 20:19:08 UTC; jwambaug
Author: John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>),
  Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>),
  Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>),
  Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>),
  Mark Sfeir [aut],
  Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>),
  Jimena Davis [ctb],
  James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>),
  Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>),
  Barbara Wetmore [ctb],
  Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)
Maintainer: John Wambaugh <wambaugh.john@epa.gov>
Repository: CRAN
Date/Publication: 2020-03-02 06:00:12 UTC
Built: R 3.5.3; x86_64-w64-mingw32; 2020-04-22 06:56:02 UTC; windows
Archs: i386, x64
