Package: MM2S
Type: Package
Version: 1.0.6
Date: 2019-03-12
Title: Single-Sample Classifier of Medulloblastoma Subtypes for
        Medulloblastoma Patient Samples, Mouse Models, and Cell Lines
Description: A single-sample classifier that generates Medulloblastoma (MB) subtype predictions for single-samples of human Medulloblastoma (MB) patients and model systems, including cell lines and mouse-models. The MM2S algorithm uses a systems-based methodology that facilitates application of the algorithm on samples irrespective of their platform or source of origin. MM2S demonstrates > 96% accuracy for patients of well-characterized normal cerebellum, Wingless (WNT), or Sonic hedgehog (SHH) subtypes, and the less-characterized Group4 (86%) and Group3 (78.2%). MM2S also enables classification of MB cell lines and mouse models into their human counterparts.This package contains function for implementing the classifier onto human data and mouse data, as well as graphical rendering of the results as PCA (Principal Component Analysis) plots and heatmaps. Deena Gendoo and Benjamin Haibe-Kains (2016) <doi:10.1186/s13029-016-0053-y>.
Author: Deena M.A. Gendoo  <deena.gendoo@utoronto.ca>, Benjamin Haibe-Kains <benjamin.haibe.kains@utoronto.ca>
Maintainer: Benjamin Haibe-Kains <benjamin.haibe.kains@utoronto.ca>
Depends: GSVA (>= 1.13.1), kknn (>= 1.2-5), parallel, lattice,
        pheatmap, R (>= 2.10)
Suggests: knitr, MM2Sdata
Imports: datasets, grDevices, graphics, stats, utils
VignetteBuilder: knitr
License: GPL-3
biocViews: MM2Sdata, Cancer, Classification, Microarray, Software,
        Visualization
URL:
        https://scfbm.biomedcentral.com/articles/10.1186/s13029-016-0053-y,
        http://www.sciencedirect.com/science/article/pii/S0888754315000774,
        http://www.pmgenomics.ca/bhklab/software/mm2s
LazyData: yes
NeedsCompilation: no
Packaged: 2019-03-21 20:41:26 UTC; gangesh
Repository: CRAN
Date/Publication: 2019-03-22 09:53:44 UTC
Built: R 3.5.3; ; 2020-04-22 07:01:40 UTC; windows
