Package: httk
Version: 1.9.2
Date: 2019-04-24
Title: High-Throughput Toxicokinetics
Description: Functions and data tables for simulation and statistical analysis 
             of chemical toxicokinetics ("TK") as in Pearce et al. (2017) 
             <doi:10.18637/jss.v079.i04>. Chemical-specific in vitro 
             data have been obtained from relatively high throughput 
             experiments. Both physiologically-based ("PBTK") and empirical 
             (e.g., one compartment) "TK" models can be parameterized for 
             several hundred chemicals and multiple species. These models are 
             solved efficiently, often using compiled (C-based) code. A Monte 
             Carlo sampler is included for simulating biological variability 
             (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>) 
             and measurement limitations. Calibrated methods are included for 
             predicting tissue:plasma partition coefficients and volume of 
             distribution 
             (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>). 
             These functions and data provide a set of tools for 
             in vitro-in vivo extrapolation ("IVIVE") of high throughput 
             screening data (e.g., Tox21, ToxCast) to real-world exposures via 
             reverse dosimetry (also known as "RTK") 
             (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).
Authors@R: c(
           person("John", "Wambaugh", email = "wambaugh.john@epa.gov", role = c("aut", "cre")), 
           person("Robert", "Pearce", role = c("aut")), 
           person("Caroline", "Ring", email = "cring@toxstrategies.com", role = c("aut")), 
           person("Greg", "Honda", email = "honda.gregory@epa.gov", role = c("aut")), 
           person("Jimena", "Davis", role = c("ctb")), 
           person("Nisha", "Sipes", email = "nisha.sipes@nih.gov", role = c("ctb")), 
           person("Barbara", "Wetmore", email = "wetmore.barbara@epa.gov", role = c("ctb")), 
           person("Woodrow", "Setzer", role = c("ctb"))
           )
Depends: R (>= 2.10)
Imports: deSolve, msm, data.table, survey, mvtnorm, truncnorm, stats,
        utils, magrittr
Suggests: ggplot2, knitr, rmarkdown, R.rsp, GGally, gplots, scales,
        EnvStats, MASS, RColorBrewer, TeachingDemos, classInt, ks,
        reshape2, gdata, viridis, CensRegMod, gmodels, colorspace
License: GPL-3
LazyData: true
VignetteBuilder: knitr, R.rsp
RoxygenNote: 6.1.1
URL:
        https://www.epa.gov/chemical-research/rapid-chemical-exposure-and-dose-research
BugReports: https://github.com/USEPA/CompTox-ExpoCast-httk
NeedsCompilation: yes
Packaged: 2019-04-25 15:19:48 UTC; jwambaug
Author: John Wambaugh [aut, cre],
  Robert Pearce [aut],
  Caroline Ring [aut],
  Greg Honda [aut],
  Jimena Davis [ctb],
  Nisha Sipes [ctb],
  Barbara Wetmore [ctb],
  Woodrow Setzer [ctb]
Maintainer: John Wambaugh <wambaugh.john@epa.gov>
Repository: CRAN
Date/Publication: 2019-04-25 16:10:02 UTC
Built: R 3.4.4; x86_64-w64-mingw32; 2019-04-25 17:08:04 UTC; windows
Archs: i386, x64
