# A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for Phase I Clinical Trials

## Documentation for package ‘dfpk’ version 2.1.0

- DESCRIPTION file.

## Help Pages

dfpk-package | A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for Phase I Clinical Trials.
AUC_estim | Estimation of the area under the curve, AUC.
dfpk | A Bayesian Dose-Finding Design using Pharmacokinetics(PK) for Phase I Clinical Trials.
Dose-class | An S4 class to present the next recommended dose level in an ongoing trial.
dosefinding-class | An S4 class to represent a dosefinding results.
dtox | Dose finding method DTOX.
invlogit | Inverse logistic functions.
nextDose | Next dose determination of a phase I clinical trial.
nsim | Simulate one or more Phase I clinical trial(s) using the PK measure in the dose finding design.
pk.estim | The pharmacokinetic's (PK) measure of exposure.
pkcov | Dose finding method PKCOV.
pkcrm | Dose finding method PKCRM.
pklogit | Dose finding method PKLOGIT.
pkpop | Dose finding method PKPOP.
pktox | Dose finding method PKTOX.
plotConc | The generic function of plot.conc.
plotConc-method | The graphical representation of the drug's concentration in the plasma at time t after the drug administration.
plotDose | The generic function of the plot.dose.
plotDose-method | The graphical representation of dose escalation for each patient in the trial.
scen-class | An S4 class to represent a simulated scenarios.
scenarios | Generate new data from a scenarios.
show-method | S4 Methods for Function 'show'
show-methods | S4 Methods for Function 'show'
stan_f | The data stan_f includes all the Stan models that dfpk package uses.