## ----echo=FALSE,results='hide'----------------------------
library("knitr")
options(prompt = "R> ", continue = " ", width = 60, useFancyQuotes = FALSE)
opts_chunk$set(tidy=TRUE, highlight=FALSE, background="white")
opts_chunk$set(dev=c('pdf','postscript'), fig.path='cancerfigure/')

## ----message=FALSE, eval=FALSE----------------------------
#  #The data files below were downloaded on June 1, 2016
#  require("gdata")
#  bc <- t(read.delim("GSE20194_series_matrix.txt.gz",sep="",header=FALSE,skip=80))
#  colnames(bc) <- bc[1,]
#  bc <- bc[-1, -c(1, 2)]
#  ###The last column is empty with variable name !series_matrix_table_end, thus omitted
#  bc <- bc[, -22284]
#  mode(bc) <- "numeric" ### convert character to numeric
#  dat1 <- read.xls("GSE20194_MDACC_Sample_Info.xls", sheet=1, header=TRUE)
#  y <- dat1$characteristics..ER_status
#  y <- ifelse(y=="P", 1, -1)
#  table(y)
#  res <- rep(NA, dim(bc)[2])
#  for(i in 1:dim(bc)[2])
#  res[i] <- abs(t.test(bc[,i]~y)$statistic)
#  ### find 3000 largest absolute value of t-statistic
#  tmp <- order(res, decreasing=TRUE)[1:3000]
#  dat <- bc[, tmp]
#  ### standardize variables
#  dat <- scale(dat)

## ----message=FALSE----------------------------------------
nrun <- 100 
per <- c(0, 0.05, 0.10, 0.15)
learntype <- c("tree", "ls")[2]
tuning <- "error"
n.cores <- 5 
plot.it <- TRUE
### robust tuning parameters used in bst/rbst function
s <- c(0.9, 1.01,0.5, -0.2, 0.8, -0.5, -0.2)
nu <- c(0.01, 0.1, 0.01, rep(0.1, 4))        
m <- 100  ### boosting iteration number
### whether to truncate the predicted values in each boosting iteration?
ctr.trun <- c(TRUE, rep(FALSE, 6))
### used in bst function
bsttype <- c("closs", "gloss", "qloss", "binom", "binom", "hinge", "expo")
### and corresponding labels
bsttype1 <- c("ClossBoost", "GlossBoost", "QlossBoost", "LogitBoost", "LogitBoost", "HingeBoost", "AdaBoost")
### used in rbst function
rbsttype <- c("closs", "gloss", "qloss", "tbinom", "binomd", "thinge", "texpo")
### and corresponding labels
rbsttype1 <- c("ClossBoostQM", "GlossBoostQM", "QlossBoostQM", "TLogitBoost", "DlogitBoost", "THingeBoost", "TAdaBoost")

## ----cancer, fig.show='hold', eval=FALSE------------------
#  summary7 <- function(x) c(summary(x), sd=sd(x))
#  ptm <- proc.time()
#  for(k in 1:7){   ### k controls which family in bst, and rfamily in rbst
#    err.m1 <- err.m2 <- nvar.m1 <- nvar.m2 <- errbest.m1 <- errbest.m2 <- matrix(NA, ncol=4, nrow=nrun)
#    mstopbest.m1 <- mstopbest.m2 <- mstopcv.m1 <- mstopcv.m2 <- matrix(NA, ncol=4, nrow=nrun)
#    colnames(err.m1) <- colnames(err.m2) <- c("cont-0%", "cont-5%", "cont-10%", "cont-15%")
#    colnames(mstopcv.m1) <- colnames(mstopcv.m2) <- colnames(err.m1)
#    colnames(nvar.m1) <- colnames(nvar.m2) <- colnames(err.m1)
#    colnames(errbest.m1) <- colnames(errbest.m2) <- colnames(err.m1)
#    colnames(mstopbest.m1) <- colnames(mstopbest.m2) <- colnames(err.m1)
#    for (ii in 1:nrun){
#      set.seed(1000+ii)
#      trid <- c(sample(which(y==1))[1:50], sample(which(y==-1))[1:50])
#      dtr <- dat[trid, ]
#      dte <- dat[-trid, ]
#      ytrold <- y[trid]
#      yte <- y[-trid]
#      ### number of patients/no. variables in training and test data
#      dim(dtr)
#      dim(dte)
#      ###randomly contaminate data
#      ntr <- length(trid)
#      set.seed(1000+ii)
#      con <- sample(ntr)
#      for(j in 1){     ### controls learntype
#        for(i in 1:4){    ### i controls how many percentage of data contaminated
#          ytr <- ytrold
#          percon <- per[i]
#          ### randomly flip labels of the samples in training set according to pre-defined contamination level
#          if(percon > 0){
#            ji <- con[1:(percon*ntr)]
#            ytr[ji] <- -ytrold[ji]
#          }
#          dat.m1 <- bst(x=dtr, y=ytr, ctrl = bst_control(mstop=m, center=FALSE, trace=FALSE, nu=nu[k], s=s[k], trun=ctr.trun[k]), family = bsttype[k],
#          learner = learntype[j])
#          err1 <- predict(dat.m1, newdata=dte, newy=yte, type="error")
#          err1tr <- predict(dat.m1, newdata=dtr, newy=ytr, type="loss")
#          ### cross-validation to select best boosting iteration
#          set.seed(1000+ii)
#          cvm1 <- cv.bst(x=dtr, y=ytr, K=5, n.cores=n.cores, ctrl = bst_control(mstop=m, center=FALSE, trace=FALSE, nu=nu[k], s=s[k], trun=ctr.trun[k]), family = bsttype[k],
#          learner = learntype[j], main=bsttype[k], type=tuning, plot.it=FALSE)
#          optmstop <- max(10, which.min(cvm1$cv))
#          err.m1[ii, i] <- err1[optmstop]
#          nvar.m1[ii, i] <- nsel(dat.m1, optmstop)[optmstop]
#          errbest.m1[ii, i] <- min(err1)
#          mstopbest.m1[ii, i] <- which.min(err1)
#          mstopcv.m1[ii, i] <- optmstop
#          dat.m2 <- rbst(x=dtr, y=ytr, ctrl = bst_control(mstop=m, iter=100, nu=nu[k], s=s[k], trun=ctr.trun[k], center=FALSE, trace=FALSE), rfamily = rbsttype[k], learner = learntype[j])
#          err2 <- predict(dat.m2, newdata=dte, newy=yte, type="error")
#          err2tr <- predict(dat.m2, newdata=dtr, newy=ytr, type="loss")
#          ### cross-validation to select best boosting iteration
#          set.seed(1000+ii)
#          cvm2 <- cv.rbst(x=dtr, y=ytr, K=5, n.cores=n.cores, ctrl = bst_control(mstop=m, iter=100, nu=nu[k], s=s[k], trun=ctr.trun[k], center=FALSE, trace=FALSE), rfamily = rbsttype[k],
#          learner = learntype[j], main=rbsttype[k], type=tuning, plot.it=FALSE)
#          optmstop <- max(10, which.min(cvm2$cv))
#          err.m2[ii, i] <- err2[optmstop]
#          nvar.m2[ii, i] <- nsel(dat.m2, optmstop)[optmstop]
#          errbest.m2[ii, i] <- min(err2)
#          mstopbest.m2[ii, i] <- which.min(err2)
#          mstopcv.m2[ii, i] <- optmstop
#        }
#      }
#      if(ii %% nrun ==0){
#      if(bsttype[k]%in% c("closs", "gloss", "qloss"))
#      cat(paste("\nbst family ", bsttype1[k], ", s=", s[k], ", nu=", nu[k], sep=""), "\n")
#      if(bsttype[k]%in% c("binom", "hinge", "expo"))
#      cat(paste("\nbst family ", bsttype1[k], ", nu=", nu[k], sep=""), "\n")
#      cat("best misclassification error from bst\n")
#      print(round(apply(errbest.m1, 2, summary7),4))
#      cat("CV based misclassification error from bst\n")
#      print(round(apply(err.m1, 2, summary7),4))
#      cat("best mstop with best misclassification error from bst\n")
#      print(round(apply(mstopbest.m1, 2, summary7),0))
#      cat("best mstop with CV from bst\n")
#      print(round(apply(mstopcv.m1, 2, summary7), 0))
#      cat("nvar from bst\n")
#      print(round(apply(nvar.m1, 2, summary7),1))
#  
#      cat(paste("\nrbst family ", rbsttype1[k], ", s=", s[k], ", nu=", nu[k], sep=""), "\n")
#      cat("\nbest misclassification error from rbst\n")
#      print(round(apply(errbest.m2, 2, summary7),4))
#      cat("CV based misclassification error from rbst\n")
#      print(round(apply(err.m2, 2, summary7),4))
#      cat("best mstop with best misclassification error from rbst\n")
#      print(round(apply(mstopbest.m2, 2, summary7),0))
#      cat("best mstop with CV from rbst\n")
#      print(round(apply(mstopcv.m2, 2, summary7),0))
#      cat("nvar from rbst\n")
#      print(round(apply(nvar.m2, 2, summary7),1))
#      res <- list(err.m1=err.m1, nvar.m1=nvar.m1,
#      errbest.m1=errbest.m1,
#      mstopbest.m1=mstopbest.m1,
#      mstopcv.m1=mstopcv.m1,
#      err.m2=err.m2, nvar.m2=nvar.m2,
#      errbest.m2=errbest.m2,
#      mstopbest.m2=mstopbest.m2,
#      mstopcv.m2=mstopcv.m2,
#      s=s[k], nu=nu[k], trun=ctr.trun[k], family = bsttype[k], rfamily = rbsttype[k])
#      if(plot.it){
#        par(mfrow=c(2, 1))
#        boxplot(err.m1, main="Misclassification error", subset="", sub=bsttype1[k])
#        boxplot(err.m2, main="Misclassification error", subset="", sub=rbsttype1[k])
#        boxplot(nvar.m1, main="No. variables", subset="", sub=bsttype1[k])
#        boxplot(nvar.m2, main="No. variables", subset="", sub=rbsttype1[k])
#      }
#      check <- FALSE
#      if(check){
#        par(mfrow=c(3, 1))
#        title <- paste('percentage of contamination ', percon, sep='')
#        plot(err2tr, main=title, ylab="Loss value", xlab="Iteration", type="l", lty="dashed", col="red")
#        points(err1tr, type="l", lty="solid", col="black")
#        legend("topright", c(bsttype1[k], rbsttype1[k]), lty=c("solid", "dashed"), col=c("black","red"))
#        plot(err2, main=title, ylab="Misclassification error", xlab="Iteration", type="l", lty="dashed", col="red")
#        points(err1, type="l")
#        legend("bottomright", c(bsttype1[k], rbsttype1[k]), lty=c("solid", "dashed"), col=c("black","red"))
#        plot(nsel(dat.m2, m), main=title, ylab="No. variables", xlab="Iteration", lty="dashed", col="red", type="l")
#        points(nsel(dat.m1, m), ylab="No. variables", xlab="Iteration", lty="solid", type="l", col="black")
#        legend("bottomright", c(bsttype1[k], rbsttype1[k]), lty=c("solid", "dashed"), col=c("black","red"))
#      }
#    }
#  }
#  }
#    print(proc.time()-ptm)

## ----sessionInfo------------------------------------------
sessionInfo();

