Package: MiRSEA
Type: Package
Version: 1.1
Date: 2015-06-30
Title: 'MicroRNA' Set Enrichment Analysis
Author: Junwei Han, Siyao Liu 
Maintainer: Junwei Han <hanjunwei1981@163.com>
Description: The tools for 'MicroRNA Set Enrichment Analysis' can identify risk pathways(or prior gene sets) regulated by microRNA set in the context of microRNA expression data. (1) This package constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); 'Reactome'; 'Biocarta') and the target gene sets of microRNA are provided by four databases('TarBaseV6.0'; 'mir2Disease'; 'miRecords'; 'miRTarBase';). (2) This package can quantify the change of correlation between microRNA for each pathway(or prior gene set) based on a microRNA expression data with cases and controls. (3) This package uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway , which reflects the degree to which a given pathway is associated with the specific phenotype. (4) This package can provide the visualization of the results.
Collate: Corrp2miRfile.R EnrichmentScore.R S2N.R MirSEA.R MsReport.R
        GetExampleData.R getEnvironmentData.R GetMiRTargetData.R
        GetPathwayData.R PlotCorrelation.R PlotHeatMap.R
        PlotRunEnrichment.R
LazyData: Yes
Depends: R (>= 2.15.1)
Suggests: stats,graphics,grDevices
License: GPL (>= 2)
biocViews: Statistics, Pathways, microRNA, enrichment analysis
Packaged: 2015-07-01 02:49:17 UTC; liu
NeedsCompilation: no
Repository: CRAN
Date/Publication: 2015-07-01 11:30:03
Built: R 3.2.5; ; 2016-11-02 13:43:25 UTC; windows
