## Further Information

- The model is a simpler version of a previously published model in (Handel, Longini, and Antia 2009).
- For this app, the underlying function running the simulation is called `simulate_evolution.R`. You can call this function directly, without going through the shiny app. Check the help file for the function for more information.
- If you call the function directly, you need to process the results returned from this function and produce useful output (such as a plot) yourself.
- You can also modify this R function for your own purposes. To find out how to do that, type `?DSAIDE` at the R console.

### References

Handel, Andreas, Ira M Longini Jr, and Rustom Antia. 2009. “Antiviral Resistance and the Control of Pandemic Influenza: The Roles of Stochasticity, Evolution and Model Details.” J Theor Biol 256 (1). Department of Biology, Emory University, Atlanta, GA 30322, USA. andreas.handel@gmail.com: 117–25. doi:10.1016/j.jtbi.2008.09.021.